Alimentazione e rischi di cancro: studio prospettico EPIC

Diet and risks of cancer: EPIC prospective investigation

OBIETTIVI GENERALI E SINTESI PROGETTO

EPIC (European Prospective Investigation into Cancer and Nutrition) è uno studio europeo avviato nel 1993 al fine di indagare i rapporti tra alimentazione e tumori. Lo studio ha poi ampliato i propri obiettivi, includendo nell'analisi le interazioni geni e ambiente nello sviluppo di patologie croniche tra le quali: tumori, malattie cerebro e cardiovascolari, diabete, malattie neurologiche, malattie infiammatorie dell'intestino e malattie autoimmuni.

Lo studio è multicentrico e comprende le coorti reclutate in 9 Paesi europei per un totale di circa 400mila partecipanti adulti sani.

MATERIALI, METODI E RISULTATI ATTESI

A marzo 1998 si è concluso il reclutamento di circa 47mila soggetti in Italia di età 35-64 anni, reclutati nelle aree di Torino (10.604), Firenze, Napoli, Ragusa e Varese.
I volontari hanno compilato un questionario contenente le immagini dei piatti più frequentemente consumati, volto a rilevare i consumi abituali dei principali cibi nel corso dell’ultimo anno e un questionario su abitudini personali e altre esposizioni (fumo, esposizioni lavorative, comportamenti sessuali, patologie precedenti ecc.). Inoltre, a un sottoinsieme casuale di circa il 10% dei volontari è stata somministrata un'intervista “24-ore” che mira alla rilevazione dettagliata dei consumi alimentari delle 24 ore precedenti. Per tutti i volontari sono state raccolte le misure antropometriche, la pressione arteriosa e il polso e un campione di sangue conservato in aliquote in azoto liquido.

I volontari, che hanno tutti firmato un modulo di consenso informato, vengono seguiti tramite linkage periodici con i registri  tumori, gli archivi sanitari correnti, la documentazioni clinica e i certificati di decesso per individuare i casi incidenti e prevalenti per le diverse patologie.

STATO DI AVANZAMENTO AL 31/12/2018

Routinariamente sono effettuati follow-up di mortalità e follow-up di incidenza per tutti i tumori. Ad oggi il follow-up di incidenza di tumori è aggiornato al 31/12/2012 mentre quello di mortalità al 31/12/2013.

Sulla base di specifici progetti vengono effettuati follow-up di incidenza per malattie croniche non tumorali.

RISORSE E FINANZIAMENTI

L’indagine è stata finanziata dalla Comunità Europea e dall’Associazione Italiana per la Ricerca sul Cancro (AIRC).

COLLABORATORI

Laura Fiorini, Fulvio Ricceri.

PUBBLICAZIONI

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